The KIF26B Polyclonal Antibody (PACO35838) is a valuable tool for researchers studying KIF26B, a kinesin-like protein involved in intracellular transport and cell division. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the KIF26B protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it well-suited for investigations in cell biology and cancer research.KIF26B is known for its role in regulating microtubule dynamics and cell migration, making it a key player in processes such as organelle transport and cytoskeletal rearrangement.
Its functions have been linked to various cellular processes and abnormalities, making it a potential target for therapeutic interventions in diseases like cancer and neurodegenerative disorders. Understanding the mechanisms of KIF26B action is crucial for developing targeted treatments that exploit its functions or correct any dysregulation that may contribute to disease pathology.
Antibody Name:
KIF26B Antibody (PACO35838)
Antibody SKU:
PACO35838
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Kinesin-like protein KIF26B protein (8-133AA)
Immunohistochemistry of paraffin-embedded human breast cancer using PACO35838 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO35838 at dilution of 1:100.
Background:
Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules.
Synonyms:
Kinesin-like protein KIF26B, KIF26B
UniProt Protein Function:
KIF26B: Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Belongs to the kinesin-like protein family. KIF26 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motor; Microtubule-bindingChromosomal Location of Human Ortholog: 1q44Cellular Component: cytoplasm; kinesin complex; microtubuleMolecular Function: ATP binding; microtubule binding; plus-end-directed microtubule motor activityBiological Process: axon guidance; cytoskeleton-dependent intracellular transport; establishment of cell polarity; metabolic process; microtubule-based movement; positive regulation of cell-cell adhesion; protein localization
