The KIF24 Polyclonal Antibody (PACO36366) is a valuable tool for research related to KIF24, a kinesin motor protein that plays a role in cell division and intracellular transport. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in applications such as Western blotting. By binding to the KIF24 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in cell biology and cancer research.
KIF24 is essential for proper cell division and the maintenance of cellular organization, making it a key player in processes such as mitosis and cytokinesis. Its dysregulation has been implicated in various diseases, including cancer, where abnormal cell division and proliferation occur. By studying the function of KIF24, researchers can gain a better understanding of its role in disease development and potentially identify new therapeutic targets for intervention.
Antibody Name:
KIF24 Antibody (PACO36366)
Antibody SKU:
PACO36366
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Kinesin-like protein KIF24 protein (1168-1368AA)
Immunohistochemistry of paraffin-embedded human melanoma using PACO36366 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO36366 at dilution of 1:100.
Background:
Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation.
Synonyms:
Kinesin-like protein KIF24, KIF24, C9orf48
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]
