The KIF1B Polyclonal Antibody (CAB6638) is a valuable tool for researchers studying KIF1B, a kinesin motor protein involved in intracellular transport and neuronal development. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the KIF1B protein, this antibody allows for the detection and analysis of KIF1B in various cell types, making it an excellent choice for studies in neuroscience and cell biology.KIF1B plays a crucial role in the transport of cargo along microtubules in neurons, contributing to synaptic function and neuronal viability.
Dysregulation of KIF1B has been implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Huntington's disease, making it a target of interest for researchers seeking to understand the molecular mechanisms underlying these conditions. By investigating the function of KIF1B, scientists can gain insights into its role in neuronal health and potentially develop novel therapeutic strategies for neurodegenerative disorders.
Product Name:
KIF1B Rabbit Polyclonal Antibody
SKU:
CAB6638
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1501-1770 of human KIF1B (NP_055889.2).
Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Predicted to be involved in chemical synaptic transmission; dense core granule cytoskeletal transport; and vesicle-mediated transport. Predicted to act upstream of or within mitochondrion transport along microtubule. Predicted to be located in cytoplasmic vesicle membrane and neuron projection. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including axon; dendrite; and microtubule. Implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Biomarker of hepatocellular carcinoma.
Purification Method:
Affinity purification
Gene ID:
23095
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from SKOV3 cells, using KIF1B Rabbit pAb (CAB6638) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
