The KIF15 Polyclonal Antibody (PAC057476) is a valuable tool for researchers studying KIF15, a kinesin motor protein involved in cell division and intracellular transport. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting KIF15 in human samples, making it a reliable choice for Western blot analysis.KIF15 plays a crucial role in regulating mitotic spindle dynamics and chromosome alignment, making it a key player in cell division processes.
Dysregulation of KIF15 has been associated with various diseases, including cancer, making it an attractive target for further investigation.By using the KIF15 Polyclonal Antibody, researchers can gain insight into the function and regulation of KIF15 in different cell types and disease contexts. This antibody is an essential tool for studies in cell biology, cancer research, and drug development aimed at targeting KIF15 for therapeutic purposes.
Antibody Name:
KIF15 Antibody (PACO57476)
Antibody SKU:
PACO57476
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Kinesin-like protein KIF15 protein (1-129AA)
Immunofluorescence staining of Hela cells with PACO57476 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.
Synonyms:
Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62), KIF15, KLP2 KNSL7
UniProt Protein Function:
KIF15: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Belongs to the kinesin-like protein family. KLP2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Motor; Microtubule-bindingChromosomal Location of Human Ortholog: 3p21.31Cellular Component: centrosome; cytosol; membrane; plus-end kinesin complexMolecular Function: ATPase activity; DNA binding; microtubule motor activity; motor activityBiological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; microtubule-based movement; mitosis; retrograde vesicle-mediated transport, Golgi to ER
