KIF14 Rabbit Polyclonal Antibody (CAB10275)
- SKU:
- CAB10275
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | KIF14 Rabbit Polyclonal Antibody |
SKU: | CAB10275 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1399-1648 of human KIF14 (NP_055690.1). |
Sequence: | LENG NNKA ASVQ EEFM DAVC DGVG LGMK ILLD SGLE KAKE LQHE LFRQ CTKN EVTK EMKT NAMG LIRS LENI FAES KIKS FRRQ VQEE NFEY QDFK RMVN RAPE FLKL KHCL EKAI EIII SALK GCHS DINL LQTC VESI RNLA SDFY SDFS VPST SVGS YESR VTHI VHQE LESL AKSL LFCF ESEE SPDL LKPW ETYN QNTK EEHQ QSKS SGID GSKN KGVP KRVY ELHG SSPA VSSE ECTP SRIQ WV |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | MKS12; MCPH20; KIF14 |
Positive Sample: | HeLa,HL-60 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Midbody, Nucleus, cytoskeleton, spindle. |
Calculated MW: | 186kDa |
Observed MW: | 190kDa |
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 9928 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |