KIDINS220 Antibody (PACO51670)
- SKU:
- PACO51670
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KIDINS220 Antibody (PACO51670)
The Kidins220 Polyclonal Antibody (PAC051670) is a valuable tool for researchers studying Kidins220, a protein involved in neuronal signaling and neuroprotection. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the Kidins220 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in neuroscience and neurology.Kidins220, also known as an ankyrin repeat-rich membrane spanning protein, plays a crucial role in regulating neuronal function and protecting against oxidative stress.
Its importance in neuronal signaling pathways makes it a promising target for research into neurodegenerative diseases, such as Alzheimer's and Parkinson's. Understanding the function of Kidins220 is essential for developing new therapeutic strategies aimed at preserving neurological function and preventing neurodegeneration.Overall, the Kidins220 Polyclonal Antibody offers researchers a reliable tool for investigating the complex mechanisms involving Kidins220 in neuronal signaling and neuroprotection, ultimately contributing to advancements in the field of neuroscience and the development of potential treatments for neurodegenerative disorders.
| Antibody Name: | KIDINS220 Antibody (PACO51670) |
| Antibody SKU: | PACO51670 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate. All lanes: KIDINS220 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 197, 186, 116, 195, 60 kDa. Observed band size: 197 kDa.. |
 | Immunohistochemistry of paraffin-embedded human appendix tissue using PACO51670 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO51670 at dilution of 1:100. |
| Background: | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
| Synonyms: | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein), KIDINS220, ARMS KIAA1250 |
| UniProt Protein Function: | KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 2p24 Cellular Component: nucleoplasm; protein complex; membrane; late endosome; integral to membrane; cytosol Molecular Function:PDZ domain binding Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; in utero embryonic development; dendrite morphogenesis; cytoplasmic transport |
| UniProt Code: | Q9ULH0 |
| NCBI GenInfo Identifier: | 172044825 |
| NCBI Gene ID: | 57498 |
| NCBI Accession: | Q9ULH0.3 |
| UniProt Secondary Accession: | Q9ULH0,Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42 A1L4N4, |
| UniProt Related Accession: | Q9ULH0 |
| Molecular Weight: | 1771 |
| NCBI Full Name: | Kinase D-interacting substrate of 220 kDa |
| NCBI Synonym Full Names: | kinase D-interacting substrate, 220kDa |
| NCBI Official Symbol: | KIDINS220Â Â |
| NCBI Official Synonym Symbols: | ARMSÂ Â |
| NCBI Protein Information: | kinase D-interacting substrate of 220 kDa; truncated KIDINS220; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane-spanning protein |
| UniProt Protein Name: | Kinase D-interacting substrate of 220 kDa |
| UniProt Synonym Protein Names: | Ankyrin repeat-rich membrane-spanning protein |
| Protein Family: | Kinase D-interacting substrate |
| UniProt Gene Name: | KIDINS220Â Â |
| UniProt Entry Name: | KDIS_HUMAN |
| Antibodies |
| KIDINS220 Antibody (PACO10091) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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