KIDINS220 Antibody (PACO10091)
- SKU:
- PACO10091
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | KIDINS220 Antibody (PACO10091) |
| Antibody SKU: | PACO10091 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human KIDINS220 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | kinase D-interacting substrate, 220kDa;KIDINS220;ARMS;MGC163482 ; |
| UniProt Protein Function: | KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 2p24 Cellular Component: nucleoplasm; protein complex; membrane; late endosome; integral to membrane; cytosol Molecular Function:PDZ domain binding Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; in utero embryonic development; dendrite morphogenesis; cytoplasmic transport |
| UniProt Code: | Q9ULH0 |
| NCBI GenInfo Identifier: | 172044825 |
| NCBI Gene ID: | 57498 |
| NCBI Accession: | Q9ULH0.3 |
| UniProt Secondary Accession: | Q9ULH0,Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42 A1L4N4, |
| UniProt Related Accession: | Q9ULH0 |
| Molecular Weight: | 1771 |
| NCBI Full Name: | Kinase D-interacting substrate of 220 kDa |
| NCBI Synonym Full Names: | kinase D-interacting substrate, 220kDa |
| NCBI Official Symbol: | KIDINS220Â Â |
| NCBI Official Synonym Symbols: | ARMSÂ Â |
| NCBI Protein Information: | kinase D-interacting substrate of 220 kDa; truncated KIDINS220; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane-spanning protein |
| UniProt Protein Name: | Kinase D-interacting substrate of 220 kDa |
| UniProt Synonym Protein Names: | Ankyrin repeat-rich membrane-spanning protein |
| Protein Family: | Kinase D-interacting substrate |
| UniProt Gene Name: | KIDINS220Â Â |
| UniProt Entry Name: | KDIS_HUMAN |
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