null

KIDINS220 Antibody (PACO10091)

SKU:
PACO10091
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

system_update_altDatasheetsystem_update_altMSDS

KIDINS220 Antibody (PACO10091)

The Kidins220 Polyclonal Antibody (PACO10091) is a specialized research tool designed for the study of Kidins220, a protein essential for neuronal development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Kidins220, also known as ankyrin repeat-rich membrane spanning protein or ARMS, plays a crucial role in various neuronal processes, including neuronal differentiation, survival, and signaling. By targeting the Kidins220 protein, researchers can gain insights into the mechanisms underlying neurodevelopmental disorders, neurodegenerative diseases, and psychiatric conditions.

This antibody enables the detection and analysis of Kidins220 in a variety of cell types, making it an invaluable tool for studies in neuroscience and neurobiology. By understanding the functions and regulatory roles of Kidins220, researchers may uncover new therapeutic targets for neurological conditions and contribute to the development of novel treatments.

Antibody Name:KIDINS220 Antibody (PACO10091)
Antibody SKU:PACO10091
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human KIDINS220
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:kinase D-interacting substrate, 220kDa;KIDINS220;ARMS;MGC163482 ;
UniProt Protein Function:KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 2p24

Cellular Component: nucleoplasm; protein complex; membrane; late endosome; integral to membrane; cytosol

Molecular Function:PDZ domain binding

Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; in utero embryonic development; dendrite morphogenesis; cytoplasmic transport

UniProt Code:Q9ULH0
NCBI GenInfo Identifier:172044825
NCBI Gene ID:57498
NCBI Accession:Q9ULH0.3
UniProt Secondary Accession:Q9ULH0,Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42 A1L4N4,
UniProt Related Accession:Q9ULH0
Molecular Weight:1771
NCBI Full Name:Kinase D-interacting substrate of 220 kDa
NCBI Synonym Full Names:kinase D-interacting substrate, 220kDa
NCBI Official Symbol:KIDINS220  
NCBI Official Synonym Symbols:ARMS  
NCBI Protein Information:kinase D-interacting substrate of 220 kDa; truncated KIDINS220; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane-spanning protein
UniProt Protein Name:Kinase D-interacting substrate of 220 kDa
UniProt Synonym Protein Names:Ankyrin repeat-rich membrane-spanning protein
Protein Family:Kinase D-interacting substrate
UniProt Gene Name:KIDINS220  
UniProt Entry Name:KDIS_HUMAN

Related Products