The Keap1 Polyclonal Antibody (CAB17062) is a powerful tool for researchers studying the Keap1 protein, a key regulator of the cellular defense against oxidative stress. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the Keap1 protein, researchers can effectively study its function and regulation in various cell types.Keap1 is a crucial component of the antioxidant response pathway, playing a pivotal role in maintaining cellular homeostasis and protecting cells from oxidative damage. Dysregulation of Keap1 signaling has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By utilizing the Keap1 Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying these disease processes and potentially identify novel therapeutic targets.Overall, the Keap1 Polyclonal Antibody is a valuable tool for researchers interested in elucidating the role of Keap1 in cellular defense mechanisms and disease pathology. Its high specificity and reactivity make it an essential component of studies aimed at understanding and targeting Keap1 in the context of oxidative stress-related diseases.
Product Name:
KEAP1 Rabbit Polyclonal Antibody
SKU:
CAB17062
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 301-400 of human KEAP1 (NP_036421.2).
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9817
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KEAP1 Rabbit pAb (CAB17062) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
