The KDM8 Polyclonal Antibody (CAB11606) is a powerful tool for researchers studying histone demethylase KDM8, a protein involved in epigenetic regulation. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is optimized for use in Western blot applications. By specifically binding to KDM8, this antibody enables accurate detection and analysis of the protein in various cell types, making it ideal for investigations in the fields of chromatin biology and gene expression regulation.KDM8, a member of the Jumonji C domain-containing histone demethylase family, is crucial for demethylating histone H3 lysine 36 (H3K36) and modulating gene transcription.
Its role in epigenetic modifications makes KDM8 a key player in the regulation of cellular processes, with implications for development, differentiation, and disease progression. By elucidating the function of KDM8, researchers can gain valuable insights into epigenetic mechanisms and potentially uncover novel targets for therapeutic interventions in conditions such as cancer and genetic disorders.
Product Name:
KDM8 Rabbit Polyclonal Antibody
SKU:
CAB11606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 147-416 of human KDM8 (NP_079049.2).
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
79831
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KDM8 Rabbit pAb (CAB11606) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
