The KDM6B Polyclonal Antibody (CAB12763) is a valuable tool for researchers studying KDM6B, a histone demethylase involved in epigenetic regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for Western blot applications. By targeting the KDM6B protein, this antibody allows for the detection and analysis of KDM6B expression in various cell types, making it an essential tool for studies in epigenetics and gene regulation.KDM6B plays a crucial role in gene transcription and chromatin remodeling, making it a key player in processes such as cell differentiation and development.
Dysregulation of KDM6B has been linked to various diseases, including cancer and developmental disorders. By studying the expression and function of KDM6B, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the KDM6B Polyclonal Antibody is a valuable resource for researchers seeking to further understand the role of KDM6B in epigenetic regulation and its implication in disease pathology. Its high specificity and sensitivity make it an essential tool for studies in the fields of epigenetics, gene regulation, and disease research.
Product Name:
Kdm6b Rabbit Polyclonal Antibody
SKU:
CAB12763
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of mouse Kdm6b (NP_001017426.1).
Enables beta-catenin binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including histone H3-K27 demethylation; mesodermal cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; histone demethylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; gut; liver; metanephros; and olfactory epithelium. Orthologous to human KDM6B (lysine demethylase 6B).
Purification Method:
Affinity purification
Gene ID:
216850
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Kdm6b antibody (CAB12763) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
