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KDM6B Antibody (PACO53830)

SKU:
PACO53830
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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KDM6B Antibody (PACO53830)

The KDM6B Polyclonal Antibody (PAC053830) is a valuable tool for researchers studying the KDM6B protein, a key regulator of gene expression and chromatin structure. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for Western blot applications. By binding specifically to KDM6B, this antibody allows for precise detection and analysis in various cell types, making it an ideal choice for studies in epigenetics, cancer biology, and developmental biology.

KDM6B, also known as lysine-specific demethylase 6B, plays a critical role in histone modification and gene transcription regulation. Its involvement in pathways related to cell differentiation, proliferation, and tumorigenesis underscores its importance in understanding various biological processes and disease mechanisms. With its ability to target KDM6B, this antibody offers researchers a reliable tool for exploring the functions and potential therapeutic targets of this vital protein.

Antibody Name:KDM6B Antibody (PACO53830)
Antibody SKU:PACO53830
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Lysine-specific demethylase 6B protein (1530-1682AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescent analysis of Hela cells using PACO53830 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Synonyms:Lysine-specific demethylase 6B (EC 1.14.11) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B), KDM6B, JMJD3 KIAA0346
UniProt Protein Function:JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.14.11.-Chromosomal Location of Human Ortholog: 17p13.1Cellular Component: nucleoplasm; nucleusMolecular Function: histone demethylase activity; protein bindingBiological Process: cardiac muscle cell differentiation; endothelial cell differentiation; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
UniProt Code:O15054
NCBI GenInfo Identifier:313104309
NCBI Gene ID:23135
NCBI Accession:O15054.4
UniProt Secondary Accession:O15054,Q96G33, C9IZ40
UniProt Related Accession:O15054
Molecular Weight:180,702 Da
NCBI Full Name:Lysine-specific demethylase 6B
NCBI Synonym Full Names:lysine demethylase 6B
NCBI Official Symbol:KDM6B  
NCBI Official Synonym Symbols:JMJD3  
NCBI Protein Information:lysine-specific demethylase 6B
UniProt Protein Name:Lysine-specific demethylase 6B
UniProt Synonym Protein Names:JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B
Protein Family:Lysine-specific demethylase
UniProt Gene Name:KDM6B  
UniProt Entry Name:KDM6B_HUMAN
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