KDM6A Rabbit Polyclonal Antibody (CAB8159)
- SKU:
- CAB8159
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | KDM6A Rabbit Polyclonal Antibody |
SKU: | CAB8159 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-700 of mouse KDM6A (NP_033509.1). |
Sequence: | MPSV SQPG VHTA CPRQ TLAN GPFS AGHV PCST SRTL GSTD TVLI GNNH VTGS GSNG NVPY LQRN APTL PHNR TNLT SSTE EPWK NQLS NSTQ GLHK GPSS HLAG PNGE RPLS STGP SQHL QAAG SGIQ NQNG HPTL PSNS VTQG AALN HLS |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | Utx; KDM6A |
Positive Sample: | T-47D,THP-1(negative) |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 154kDa/157kDa |
Observed MW: | 180kDa |
Enables DNA binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and histone H3-K27 demethylation. Located in nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including early conceptus; gonad; liver; lung; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A).
Purification Method: | Affinity purification |
Gene ID: | 22289 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |