The KDM6A Polyclonal Antibody (CAB8159) is a valuable tool for researchers studying the function of KDM6A, a histone demethylase involved in gene regulation and epigenetic modifications. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the KDM6A protein, this antibody allows for the detection and analysis of KDM6A expression in various cell types, making it ideal for investigations in the fields of molecular biology and cancer research.
KDM6A, also known as UTX, plays a crucial role in chromatin remodeling and gene expression regulation. Dysregulation of KDM6A has been linked to various diseases, including cancer and developmental disorders. By studying the function of KDM6A with the help of this antibody, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
KDM6A Rabbit Polyclonal Antibody
SKU:
CAB8159
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 550-700 of mouse KDM6A (NP_033509.1).
Enables DNA binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and histone H3-K27 demethylation. Located in nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including early conceptus; gonad; liver; lung; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A).
Purification Method:
Affinity purification
Gene ID:
22289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using KDM6A Rabbit pAb (CAB8159) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
