The KDM5A Rabbit Monoclonal Antibody (CAB4755) is a valuable tool for researchers studying the KDM5A protein, a key epigenetic regulator involved in gene expression and cell differentiation processes. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity for detecting KDM5A in various sample types, particularly in Western blot applications.KDM5A, also known as JARID1A, is a histone demethylase that plays a crucial role in chromatin remodeling and transcriptional regulation. Dysregulation of KDM5A has been associated with various diseases, including cancer, developmental disorders, and neurological conditions.
By targeting KDM5A with this specific antibody, researchers can gain insights into its function and potential therapeutic implications in these disease contexts.With the ability to accurately detect and quantify KDM5A levels, researchers can further explore the molecular mechanisms underlying its biological functions and its implications for disease pathogenesis. The KDM5A Rabbit Monoclonal Antibody (CAB4755) offers a reliable and consistent tool for investigating the role of KDM5A in epigenetic regulation, making it an essential component for studies in cancer biology, developmental biology, and epigenetics.
Product Name:
KDM5A Rabbit Monoclonal Antibody
SKU:
CAB4755
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1690 of human KDM5A (P29375).
WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsChIP,2μg antibody for 10μg-15μg of Chromatin
Synonyms:
RBP2; RBBP2; RBBP-2; KDM5A
Positive Sample:
HeLa,HepG2,Mouse lung
Conjugate:
Unconjugated
Cellular Localization:
Nucleus, nucleolus.
Calculated MW:
192kDa
Observed MW:
200kDa
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.
Purification Method:
Affinity purification
Gene ID:
5927
Clone Number:
ARC1120
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using KDM5A Rabbit mAb (CAB4755) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
