The KDM5A Polyclonal Antibody (CAB7238) is a vital tool for researchers studying the function of KDM5A, a key enzyme involved in epigenetic regulation. Raised in rabbits, this antibody exhibits high specificity and sensitivity when used in Western blot applications with human samples. By binding to the KDM5A protein, researchers can accurately detect and analyze its expression levels in various cell types, making it an invaluable asset in the fields of epigenetics and cancer research.KDM5A, also known as lysine-specific demethylase 5A, plays a critical role in histone modification and gene expression regulation.
Dysregulation of KDM5A has been implicated in various diseases, including cancer, developmental disorders, and neurodegenerative diseases. By understanding the function of KDM5A, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.Overall, the KDM5A Polyclonal Antibody (CAB7238) offers researchers a reliable tool for investigating the role of KDM5A in various biological processes, paving the way for new discoveries in the fields of epigenetics and disease research.
Product Name:
KDM5A Rabbit Polyclonal Antibody
SKU:
CAB7238
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant protein of human KDM5A
Tested Applications:
WBIPChIPELISA
Recommended Dilution:
WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsChIP,5μg antibody for 10μg-15μg of Chromatin
Synonyms:
RBP2; RBBP2; RBBP-2; KDM5A
Positive Sample:
Jurkat,HeLa,MCF7
Conjugate:
Unconjugated
Cellular Localization:
Nucleus, nucleolus.
Calculated MW:
192kDa
Observed MW:
192kDa
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.
Purification Method:
Affinity purification
Gene ID:
5927
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KDM5A Rabbit pAb (CAB7238) at 1:500 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 60s.
