The KDM4C Polyclonal Antibody (CAB8485) is a valuable tool for researchers studying KDM4C, a key enzyme involved in histone demethylation and gene regulation. This antibody is raised in rabbits and exhibits high reactivity with human samples, specifically recognizing the KDM4C protein in Western blot applications.KDM4C, also known as JHDM3C, plays a crucial role in epigenetic regulation by removing methyl groups from histone proteins, thereby influencing gene expression. Dysregulation of KDM4C has been implicated in various diseases, including cancer and neurodevelopmental disorders. Understanding the function of KDM4C through the use of this antibody is essential for unraveling its role in these pathologies and identifying potential therapeutic targets.
Researchers in the fields of epigenetics, oncology, and neurobiology will find the KDM4C Polyclonal Antibody to be a valuable asset in their studies, enabling precise detection and analysis of KDM4C expression in different cell types and tissues. Its specificity and reliability make it an ideal choice for investigating the intricate mechanisms of histone demethylation and potential therapeutic interventions targeting KDM4C.
Product Name:
KDM4C Rabbit Polyclonal Antibody
SKU:
CAB8485
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 640-830 of human KDM4C (NP_055876.2).
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23081
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse brain, using KDM4C Rabbit pAb (CAB8485) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
