The KDM4B Polyclonal Antibody (CAB5824) is a high-quality research tool specifically designed for studying the protein KDM4B, an important epigenetic regulator involved in gene expression and DNA repair processes. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications, enabling accurate detection and analysis of KDM4B protein levels in various cell types.KDM4B, also known as lysine-specific demethylase 4B, plays a crucial role in chromatin remodeling and transcriptional regulation, making it a key player in cellular processes such as DNA replication and cell cycle progression.
Dysregulation of KDM4B has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions, highlighting its potential as a therapeutic target for drug development and treatment strategies.By using the KDM4B Polyclonal Antibody in research studies, scientists can gain valuable insights into the mechanisms underlying KDM4B function and its impact on cellular pathways. This antibody offers a reliable tool for investigating the role of KDM4B in disease progression and identifying novel therapeutic interventions that target epigenetic modifications for improved patient outcomes.
Product Name:
KDM4B/JMJD2B Rabbit Polyclonal Antibody
SKU:
CAB5824
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_055830.1).
Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer.
Purification Method:
Affinity purification
Gene ID:
23030
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using (CAB5824) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
