The KDM4A Rabbit Monoclonal Antibody (CAB9267) is a valuable tool for studying KDM4A, a key epigenetic regulator involved in gene expression and chromatin remodeling processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for immunohistochemistry and immunofluorescence applications.KDM4A, also known as Jumonji domain-containing protein 2A, plays a crucial role in histone demethylation and transcriptional regulation. Dysregulation of KDM4A has been linked to various diseases, including cancer, neurodevelopmental disorders, and metabolic diseases.
By targeting KDM4A with this antibody, researchers can delve deeper into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.Overall, the KDM4A Rabbit Monoclonal Antibody (CAB9267) is a valuable tool for investigating the functions of KDM4A in physiological and pathological contexts, paving the way for new insights in epigenetics and potential therapeutic interventions.
Product Name:
KDM4A Rabbit Monoclonal Antibody
SKU:
CAB9267
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 550-650 of human KDM4A (O75164).
Sequence:
GDGR VTVG EPCT RKKG SAAR SFSE RELA EVAD EYMF SLEE NKKS KGRR QPLS KLPR HHPL VLQE CVSD DETS EQLT PEEE AEET EAWA KPLS QLWQ NRPP N
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
JMJD2; JHDM3A; JMJD2A; TDRD14A; KDM4A
Positive Sample:
HeLa,NIH/3T3,SH-SY5Y
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
121kDa
Observed MW:
150kDa
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
Purification Method:
Affinity purification
Gene ID:
9682
Clone Number:
ARC1503
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KDM4A Rabbit mAb (CAB9267) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
