The KDM2B Polyclonal Antibody (CAB16017) is a valuable tool for researchers studying KDM2B, a histone demethylase involved in epigenetic regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to the KDM2B protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in epigenetics, gene regulation, and cancer research.KDM2B, also known as FBXL10, plays a crucial role in chromatin remodeling and gene expression by removing methyl groups from histone proteins. Dysregulation of KDM2B has been implicated in various diseases, including cancer, developmental disorders, and neurological conditions.
With its ability to target KDM2B, this polyclonal antibody offers researchers a powerful tool for understanding the function and regulation of this important epigenetic factor.By utilizing the KDM2B Polyclonal Antibody in their studies, researchers can gain valuable insights into the molecular mechanisms underlying epigenetic regulation and disease pathogenesis. This antibody provides a reliable means of investigating KDM2B protein levels and activity, ultimately contributing to advancements in fields such as cancer biology, developmental biology, and epigenetics research.
Product Name:
KDM2B Rabbit Polyclonal Antibody
SKU:
CAB16017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human KDM2B (XP_011537177.1).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
84678
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KDM2B Rabbit pAb (CAB16017) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
