KDM2A Rabbit Polyclonal Antibody (CAB18636)
- SKU:
- CAB18636
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | KDM2A Rabbit Polyclonal Antibody |
SKU: | CAB18636 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KDM2A (NP_036440.1). |
Sequence: | MEPE EERI RYSQ RLRG TMRR RYED DGIS DDEI EGKR TFDL EEKL HTNK YNAN FVTF MEGK DFNV EYIQ RGGL RDPL IFKN SDGL GIKM PDPD FTVN DVKM |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA; KDM2A |
Positive Sample: | HeLa,BT-474,Jurkat,Mouse liver |
Cellular Localization: | Nucleus, nucleoplasm. |
Calculated MW: | 133kDa |
Observed MW: | 126kDa |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 22992 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |