The KDM1A Polyclonal Antibody (CAB15794) is a crucial tool for researchers studying the function of KDM1A, a key enzyme involved in epigenetic regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KDM1A protein, this antibody enables precise detection and analysis of KDM1A levels in various cell types, making it an essential tool for epigenetics and cancer research.KDM1A, also known as lysine-specific demethylase 1A, plays a crucial role in the regulation of gene expression by removing methyl groups from histone proteins.
Dysregulation of KDM1A has been implicated in various diseases, including cancer and neurological disorders, highlighting the importance of understanding its function. By studying the activity of KDM1A, researchers can gain valuable insights into epigenetic mechanisms underlying disease pathogenesis, paving the way for the development of targeted therapies.
Product Name:
[KO Validated] KDM1 Rabbit Polyclonal Antibody
SKU:
CAB15794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-380 of human KDM1 (NP_055828.2).
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23028
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KDM1 Rabbit pAb (CAB15794) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
