The VDAC1 Polyclonal Antibody is a powerful tool for researchers studying the voltage-dependent anion channel 1 (VDAC1), a critical protein involved in mitochondrial function and cell death pathways. This antibody, produced in rabbits, is highly specific to human VDAC1 and has been validated for use in Western blotting applications.VDAC1 plays a key role in regulating the exchange of metabolites and ions between the mitochondria and the cytosol, making it essential for cellular energy production and apoptosis.
Dysregulation of VDAC1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders.By using the VDAC1 Polyclonal Antibody, researchers can accurately detect and quantify VDAC1 expression levels in different cell types and tissues, allowing for in-depth analysis of mitochondrial function and cell survival mechanisms. This antibody is a valuable tool for studies in cell biology, cancer research, and drug development targeting mitochondrial dysfunction.
Product Name:
[KD Validated] VDAC1 Polyclonal Antibody
SKU:
CAB21730
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC1 (NP_003365.1).
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.
Purification Method:
Affinity purification
Gene ID:
7416
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KD Validated] VDAC1 Rabbit pAb (CAB21730) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
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