The KD Validated PIN1 Monoclonal Antibody is a cutting-edge tool for researchers studying PIN1, a key regulator of cell signaling pathways and protein function. This monoclonal antibody, rigorously validated for specificity and sensitivity, is ideal for a variety of experimental techniques, including Western blotting, immunohistochemistry, and immunoprecipitation.PIN1 is a pivotal enzyme involved in the phosphorylation-dependent prolyl isomerization of key proteins, playing a crucial role in cell cycle regulation, gene transcription, and apoptosis. Dysregulation of PIN1 has been implicated in various diseases, including cancer, neurological disorders, and inflammatory conditions.
By targeting PIN1 with this highly specific monoclonal antibody, researchers can investigate its function and potential therapeutic implications in diverse biological contexts.With its reliable performance and versatility in experimental applications, the KD Validated PIN1 Monoclonal Antibody is an indispensable tool for scientists seeking to unravel the complexities of PIN1 biology and its implications for human health.
Product Name:
[KD Validated] Pin1 Monoclonal Antibody
SKU:
CAB22470
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human Pin1 (NP_006212.1).
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5300
Clone Number:
ARC57311
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and Pin1 knockdown (KD) 293T cells, using [KD Validated] Pin1 Rabbit mAb (CAB22470) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
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