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[KD Validated] Pin1 Monoclonal Antibody (CAB22470)

SKU:
CAB22470
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KD Validated] Pin1 Monoclonal Antibody
SKU:CAB22470
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human Pin1 (NP_006212.1).
Sequence:MADE EKLP PGWE KRMS RSSG RVYY FNHI TNAS QWER PSGN SSSG GKNG QGEP ARVR CSHL LVKH SQSR RPSS WRQE KITR TKEE ALEL INGY IQKI KSGE EDFE SLAS QFSD CSSA KARG DLGA FSRG QMQK PFED ASFA LRTG EMSG PVFT DSGI HIIL RTE
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:DOD; UBL5; [KD Validated] Pin1
Positive Sample:HeLa,293T,NIH/3T3,Mouse brain,PC-12,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus, Nucleus speckle.
Calculated MW:18kDa
Observed MW:Refer to figures

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Purification Method:Affinity purification
Gene ID:5300
Clone Number:ARC57311
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type(WT) and Pin1 knockdown (KD) 293T cells, using [KD Validated] Pin1 Rabbit mAb (CAB22470) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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