[KD Validated] PGC1α Polyclonal Antibody (CAB22113)
- SKU:
- CAB22113
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
Frequently bought together:
Description
Product Name: | [KD Validated] PGC1α Polyclonal Antibody |
SKU: | CAB22113 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 611-710 of human PGC1α (NP_037393.1). |
Sequence: | RTHR NSPL YVRS RSRS PYSR RPRY DSYE EYQH ERLK REEY RREY EKRE SERA KQRE RQRQ KAIE ERRV IYVG KIRP DTTR TELR DRFE VFGE IEEC TVNL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha); [KD Validated] PGC1α |
Positive Sample: | HeLa,SH-SY5Y,Mouse skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, nucleoplasm, nucleus, PML body |
Calculated MW: | 91kDa |
Observed MW: | 100kDa |
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Purification Method: | Affinity purification |
Gene ID: | 10891 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |