The PGC-1 Polyclonal Antibody is a valuable tool for researchers studying PGC-1, a key regulator of cellular metabolism and energy homeostasis. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the PGC-1 protein, this antibody enables the detection and analysis of PGC-1 levels in various cell types, making it a versatile option for studies in metabolic disorders, aging, and exercise physiology.PGC-1, also known as peroxisome proliferator-activated receptor gamma coactivator 1, is a transcriptional coactivator that plays a crucial role in regulating mitochondrial biogenesis and oxidative metabolism.
Dysregulation of PGC-1 has been implicated in a range of metabolic diseases, including diabetes, obesity, and neurodegenerative disorders. By understanding the function of PGC-1, researchers can uncover new insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.
Product Name:
[KD Validated] PGC1α Polyclonal Antibody
SKU:
CAB22113
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 611-710 of human PGC1α (NP_037393.1).
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Purification Method:
Affinity purification
Gene ID:
10891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KD Validated] PGC1α Rabbit pAb (CAB22113) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
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