The KD-Validated MT2A Polyclonal Antibody is a valuable tool for researchers studying metallothionein 2A (MT2A), a key protein involved in metal homeostasis and detoxification processes in the body. This antibody, produced in rabbits, has been rigorously validated for use in various applications, including Western blotting and immunohistochemistry.MT2A is a well-known metal-binding protein that plays a critical role in protecting cells from heavy metal toxicity and oxidative stress. Dysregulation of MT2A expression has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting MT2A with this validated antibody, researchers can analyze the expression levels and localization of MT2A in different tissues and cell types, providing valuable insights into its role in health and disease.Overall, the KD-Validated MT2A Polyclonal Antibody offers a reliable and specific tool for investigating the function of MT2A in various biological processes, making it a valuable asset for studies in toxicology, molecular biology, and biomedical research.
Product Name:
[KD Validated] MT2A Polyclonal Antibody
SKU:
CAB22103
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-61 of human MT2A (NP_005944.1).
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer.
Purification Method:
Affinity purification
Gene ID:
4502
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KD Validated] MT2A Rabbit pAb (CAB22103) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
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