The ISG15 Polyclonal Antibody is a powerful tool for researchers studying the ISG15 protein, an important factor in the regulation of the immune response and antiviral defense mechanisms. Produced by Assay Genie, this antibody is raised in rabbits and has been extensively validated for use in a variety of research applications, including Western blotting.ISG15, also known as interferon-stimulated gene 15, is a ubiquitin-like protein that plays a crucial role in the innate immune response against viral infections. By targeting proteins for degradation and modulating immune signaling pathways, ISG15 helps to eliminate infected cells and control the spread of viruses within the body.
The ISG15 Polyclonal Antibody specifically recognizes the ISG15 protein, allowing researchers to study its expression and function in different cell types and experimental conditions.This antibody is an indispensable tool for investigating the role of ISG15 in immune signaling, inflammation, and antiviral defense. By understanding the mechanisms underlying ISG15's activities, researchers can develop novel strategies for combating viral infections and immune-related disorders. Whether you are studying infectious diseases, autoimmunity, or cancer immunology, the ISG15 Polyclonal Antibody from Assay Genie will provide reliable and accurate results for your research projects.
Product Name:
[KD Validated] ISG15 Polyclonal Antibody
SKU:
CAB21995
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human ISG15 (NP_005092.1).
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
Purification Method:
Affinity purification
Gene ID:
9636
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and ISG15 knockdown (KD) HeLa cells, using [KD Validated] ISG15 Rabbit pAb (CAB21995) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
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