The Integrin Alpha 5 (ITGA5/CD49e) Monoclonal Antibody is a vital tool for researchers studying integrin α5, a cell adhesion molecule essential for cell migration, proliferation, and survival. This antibody, produced through stringent validation processes, is highly specific for human samples and is suited for Western blot and immunofluorescence applications.Integrin α5 is a key player in cell adhesion and signaling pathways, influencing processes like angiogenesis, wound healing, and cancer metastasis. By targeting Integrin α5 with this monoclonal antibody, researchers can effectively analyze its expression and function in various cell types, aiding in the investigation of diseases such as cancer, fibrosis, and cardiovascular disorders.
The validated Integrin Alpha 5 Monoclonal Antibody offers a reliable tool for gaining insights into the role of integrin α5 in physiological and pathological conditions, providing a valuable resource for advancing research in cell biology, oncology, and tissue engineering.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Purification Method:
Affinity purification
Gene ID:
3678
Clone Number:
ARC58291
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts from A-549 cells, using Integrin alpha 5 (ITGA5/CD49e) antibody (CAB22706) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
