The Gelsolin Polyclonal Antibody (AG10004) is a crucial tool for researchers studying the gelsolin protein, a key player in cell motility, apoptosis, and inflammation. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the gelsolin protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for those conducting research in cell biology, cancer biology, and immunology.
Gelsolin is involved in a wide range of cellular processes, making it a target of interest in multiple fields of study. Its role in regulating actin dynamics and cell movement makes it particularly relevant in cancer research, where aberrant cell migration is a hallmark of metastatic disease. Understanding the function of gelsolin is essential for uncovering novel therapeutic strategies for cancer and other diseases involving dysregulated cell motility.
Product Name:
[KD Validated] Gelsolin Polyclonal Antibody
SKU:
CAB22015
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 28-782 of human Gelsolin (NP_000168.1).
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2934
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using [KD Validated] Gelsolin Rabbit pAb (CAB22015) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
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