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[KD Validated] G6PD Polyclonal Antibody (CAB22242)

SKU:
CAB22242
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

[KD Validated] G6PD Polyclonal Antibody (CAB22242)

The G6PD Polyclonal Antibody (CAB22242) is a valuable tool for researchers studying glucose-6-phosphate dehydrogenase (G6PD), an enzyme involved in red blood cell metabolism and protecting cells from oxidative damage. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.G6PD deficiency is a common genetic condition that can lead to hemolytic anemia under certain conditions, making it a target of interest in research on red blood cell disorders. By specifically binding to the G6PD protein, this antibody allows for precise detection and analysis in various cell types, facilitating studies in hematology and oxidative stress-related diseases.

The role of G6PD in maintaining redox balance and cellular function highlights its importance in health and disease. Understanding the mechanisms underlying G6PD activity is crucial for developing targeted therapies for conditions such as hemolytic anemia, malaria, and metabolic disorders. The G6PD Polyclonal Antibody is a valuable tool for investigating the functions and regulation of this enzyme, advancing research in these areas.

Product Name:[KD Validated] G6PD Polyclonal Antibody
Product Code:CAB22242
Reactivity:Human, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, MCF7, C6
Cellular Location:cytoplasm, cytoplasmic side of plasma membrane, cytosol, extracellular exosome, nucleus

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 195-515 of human G6PD (NP_001035810.1).
Sequence:QIYRI DHYLG KEMVQ NLMVL RFANR IFGPI WNRDN IACVI LTFKE PFGTE GRGGY FDEFG IIRDV MQNHL LQMLC LVAME KPAST NSDDV RDEKV KVLKC ISEVQ ANNVV LGQYV GNPDG EGEAT KGYLD DPTVP RGSTT ATFAA VVLYV ENERW DGVPF ILRCG KALNE RKAEV RLQFH DVAGD IFHQQ CKRNE LVIRV QPNEA VYTKM MTKKP GMFFN PEESE LDLTY GNRYK NVKLP DAYER LILDV FCGSQ MHFVR SDELR EAWRI FTPLL HQIEL EKPKP IPYIY GSRGP TEADE LMKRV GFQYE GTYKW VNPHK L
Synonyms:G6PD1
Calculated MW:59kDa
Observed MW:59kDa

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