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[KD Validated] G6PD Polyclonal Antibody (CAB21750)

SKU:
CAB21750
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

[KD Validated] G6PD Polyclonal Antibody (CAB21750)

The G6PD Polyclonal Antibody (CAB21750) is a valuable tool for researchers studying glucose-6-phosphate dehydrogenase (G6PD), an enzyme involved in the pentose phosphate pathway. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the G6PD protein, this antibody allows for precise detection and analysis in various cell types, making it an essential component in studies related to metabolism, redox biology, and disease mechanisms.G6PD is a crucial enzyme in maintaining cellular redox balance and protecting cells from oxidative damage.

Dysregulation of G6PD activity has been implicated in various pathological conditions, including metabolic disorders, neurodegenerative diseases, and cancer. By investigating the function and regulation of G6PD, researchers can gain insight into the underlying mechanisms of these diseases and identify potential therapeutic targets.Overall, the G6PD Polyclonal Antibody is a valuable resource for researchers exploring the role of G6PD in health and disease. Its high specificity and sensitivity make it a reliable tool for conducting detailed analyses and advancing our understanding of cellular metabolism and redox signaling pathways.

Product Name:[KD Validated] G6PD Polyclonal Antibody
Product Code:CAB21750
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa
Cellular Location:cytoplasm, cytoplasmic side of plasma membrane, cytosol, extracellular exosome, nucleus

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 195-515 of human G6PD (NP_001035810.1).
Sequence:QIYRI DHYLG KEMVQ NLMVL RFANR IFGPI WNRDN IACVI LTFKE PFGTE GRGGY FDEFG IIRDV MQNHL LQMLC LVAME KPAST NSDDV RDEKV KVLKC ISEVQ ANNVV LGQYV GNPDG EGEAT KGYLD DPTVP RGSTT ATFAA VVLYV ENERW DGVPF ILRCG KALNE RKAEV RLQFH DVAGD IFHQQ CKRNE LVIRV QPNEA VYTKM MTKKP GMFFN PEESE LDLTY GNRYK NVKLP DAYER LILDV FCGSQ MHFVR SDELR EAWRI FTPLL HQIEL EKPKP IPYIY GSRGP TEADE LMKRV GFQYE GTYKW VNPHK L
Synonyms:G6PD1
Calculated MW:59kDa
Observed MW:60kDa

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