The Fosl1 Polyclonal Antibody (AB12463) is a valuable tool for researchers studying Fos-related antigen 1 (Fosl1), a transcription factor implicated in cell growth, differentiation, and embryonic development. This antibody, produced in rabbits, has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and flow cytometry.Fosl1 plays a crucial role in regulating gene expression and cell proliferation, making it a key player in pathways related to cancer, wound healing, and tissue regeneration.
By targeting Fosl1 with this antibody, researchers can gain insights into its function in different cellular processes and disease states.With its high specificity and sensitivity, the Fosl1 Polyclonal Antibody is an essential tool for investigating the role of Fosl1 in biological pathways and diseases, ultimately contributing to the development of targeted therapies and diagnostics.
Product Name:
[KD Validated] FOSL1 Polyclonal Antibody
SKU:
CAB21988
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FOSL1 (NP_005429.1?).
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type(WT) and FOSL1 knockdown (KD) U-87MG cells, using FOSL1 antibody (CAB21988) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
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