[KD Validated] eIF4E Polyclonal Antibody (CAB22681)
- SKU:
- CAB22681
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IF
- IHC
Frequently bought together:
Description
Product Name: | [KD Validated] eIF4E Polyclonal Antibody |
SKU: | CAB22681 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human eIF4E. (NP_001959.1). |
Sequence: | MATV EPET TPTP NPPT TEEE KTES NQEV ANPE HYIK HPLQ NRWA LWFF KNDK SKTW QANL RLIS KFDT VEDF WALY NHIQ LSSN LMPG CDYS LFKD GIEP |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IF/ICC,1:50 - 1:200 IHC-P,1:50 - 1:200 |
Synonyms: | CBP; EIF4F; AUTS19; EIF4E1; eIF-4E; EIF4EL1; [KD Validated] eIF4E |
Positive Sample: | 293T,HeLa,Jurkat,RAW264.7,NIH/3T3,PC-12 |
Conjugate: | Unconjugated |
Cellular Localization: | chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, extracellular exosome, glutamatergic synapse, nucleus, P-body, perinuclear region of cytoplasm, postsynaptic cytosol |
Calculated MW: | 25kDa |
Observed MW: | 29kDa |
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1977 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |