Description
Product Name: | [KD Validated] COMT Polyclonal Antibody |
SKU: | CAB23600 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 51-271 of human COMT. (NP_000745.1). |
Sequence: | MGDT KEQR ILNH VLQH AEPG NAQS VLEA IDTY CEQK EWAM NVGD KKGK IVDA VIQE HQPS VLLE LGAY CGYS AVRM ARLL SPGA RLIT IEIN PDCA AITQ RMVD FAGV KDKV TLVV GASQ DIIP QLKK KYDV DTLD MVFL DHWK DRYL PDTL LLEE CGLL RKGT VLLA DNVI CPGA PDFL AHVR GSSC FECT HYQS FLEY REVV DGLE KAIY KGPG SEAG P |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | HEL-S-98n; [KD Validated] COMT |
Positive Sample: | THP-1,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein. |
Calculated MW: | 30kDa |
Observed MW: | 28,30kDa |
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Purification Method: | Affinity purification |
Gene ID: | 1312 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |