The KD-validated BID Monoclonal Antibody is a high-quality antibody designed for research involving the BID protein, a key player in the regulation of apoptosis (programmed cell death). This monoclonal antibody, validated for use in various applications including Western blotting and immunofluorescence, specifically binds to the BID protein, allowing for accurate detection and analysis in different cell types.BID, a pro-apoptotic member of the Bcl-2 protein family, is essential for the activation of the intrinsic apoptotic pathway in response to various cellular stresses.
Dysregulation of BID has been implicated in a wide range of diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Studying the function and regulation of BID is crucial for understanding the mechanisms of cell death and developing targeted therapies for related diseases.Overall, the KD-validated BID Monoclonal Antibody offers researchers a reliable tool for investigating the role of BID in cellular processes and disease pathogenesis, ultimately advancing our knowledge of apoptosis and potential therapeutic interventions.
Product Name:
[KD Validated] Bid Monoclonal Antibody
SKU:
CAB23234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human Bid (NP_001187.1).
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found.
Purification Method:
Affinity purification
Gene ID:
637
Clone Number:
ARC59702
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using [KD Validated] Bid Rabbit mAb (CAB23234) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
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