[KD Validated] Bcl-XL Polyclonal Antibody (CAB22241)
- SKU:
- CAB22241
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | [KD Validated] Bcl-XL Polyclonal Antibody |
SKU: | CAB22241 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Bcl-XL (NP_001304848.1). |
Sequence: | MSQS NREL VVDF LSYK LSQK GYSW SQFS DVEE NRTE APEG TESE METP SAIN GNPS WHLA DSPA VNGA TGHS SSLD AREV IPMA AVKQ ALRE AGDE FELR YRRA FSDL TSQL HITP GTAY |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S; [KD Validated] Bcl-XL |
Positive Sample: | A-549,HeLa,L929,C6,PC-12 |
Conjugate: | Unconjugated |
Cellular Localization: | centrosome, cytoplasm, cytosol, endoplasmic reticulum, mitochondrial inner membrane, mitochondrial matrix, mitochondrial outer membrane, mitochondrion, nuclear membrane |
Calculated MW: | 26kDa |
Observed MW: | 30kDa |
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Purification Method: | Affinity purification |
Gene ID: | 598 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |