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[KD Validated] ABCG2 Polyclonal Antibody (CAB23066)

SKU:
CAB23066
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139

Description

[KD Validated] ABCG2 Polyclonal Antibody (CAB23066)

The ABCG2 Polyclonal Antibody (CAB10007) is a valuable tool for researchers studying the ABCG2 protein, a key player in multidrug resistance in cancer cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting ABCG2 expression in human samples, making it suitable for Western blot analysis. By binding to the ABCG2 protein, this antibody enables precise identification and quantification of ABCG2 in various cell types, facilitating research in cancer biology and drug resistance mechanisms.ABCG2, also known as breast cancer resistance protein (BCRP), is a crucial transporter protein involved in expelling chemotherapy drugs from cancer cells, contributing to treatment resistance and disease progression.

Targeting ABCG2 has emerged as a promising strategy to overcome multidrug resistance and improve cancer therapy outcomes. Therefore, thorough investigation of ABCG2 function and regulation is essential for developing effective therapeutic interventions for drug-resistant cancers.Overall, the ABCG2 Polyclonal Antibody serves as a reliable tool for researchers investigating the role of ABCG2 in cancer drug resistance and exploring novel strategies to enhance the efficacy of chemotherapeutic agents. Its high specificity and sensitivity make it a valuable asset in advancing our understanding of ABCG2 biology and potential therapeutic targets in cancer research.

Product Name:[KD Validated] ABCG2 Polyclonal Antibody
Product Code:CAB23066
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HepG2, A-549, MCF7
Cellular Location:Cell membrane, Mitochondrion membrane, Multi-pass membrane protein

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant protein of human ABCG2.
Sequence:SGLSG DVLIN GAPRP ANFKC NSGYV VQDDV VMGTL TVREN LQFSA ALRLA TTMTN HEKNE RINRV IQELG LDKVA DSKVG TQFIR GVSGG ERKRT SIGME L
Synonyms:MRX, MXR, ABCP, BCRP, BMDP, MXR1, ABC15, BCRP1, CD338, GOUT1, MXR-1, CDw338, CDw388, UAQTL1, EST157481
Calculated MW:72kDa
Observed MW:65-80kDa

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