Anti-KCNS3 Antibody (CAB7906)

Antibody Name:	Anti-KCNS3 Antibody
Antibody SKU:	CAB7906
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human KCNS3 (NP_002243.3).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	A-549, SGC-7901, HT-29, Mouse brain, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human KCNS3 (NP_002243.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MVFG EFFH RPGQ DEEL VNLN VGGF KQSV DQST LLRF PHTR LGKL LTCH SEEA ILEL CDDY SVAD KEYY FDRN PSLF RYVL NFYY TGKL HVME ELCV FSFC QEIE YWGI NELF IDSC CSNR YQER KEEN HEKD WDQK SHDV STDS SFEE SSLF EKEL EKFD TLRF GQLR KKIW IRME NPAY
Gene ID:	3790
Uniprot:	Q9BQ31
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	56kDa
Observed MW:	56kDa

Synonyms:

KCNS3, KV9.3

Background:

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

UniProt Protein Function:	Kv9.3: Potassium channel subunit. Modulates channel activity and reduces the ion flow. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 2p24 Cellular Component: cytoplasm; Golgi apparatus; integral to membrane; plasma membrane Molecular Function:delayed rectifier potassium channel activity; potassium channel regulator activity Biological Process: potassium ion transport; regulation of insulin secretion
NCBI Summary:	Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Code:	Q9BQ31
NCBI GenInfo Identifier:	311033434
NCBI Gene ID:	3790
NCBI Accession:	Q9BQ31.3
UniProt Secondary Accession:	Q9BQ31,O43651, Q4ZFY1, Q96B56, D6W520,
UniProt Related Accession:	Q9BQ31
Molecular Weight:	56,001 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily S member 3
NCBI Synonym Full Names:	potassium voltage-gated channel modifier subfamily S member 3
NCBI Official Symbol:	KCNS3
NCBI Official Synonym Symbols:	KV9.3
NCBI Protein Information:	potassium voltage-gated channel subfamily S member 3
UniProt Protein Name:	Potassium voltage-gated channel subfamily S member 3
UniProt Synonym Protein Names:	Delayed-rectifier K(+) channel alpha subunit 3; Voltage-gated potassium channel subunit Kv9.3
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNS3
UniProt Entry Name:	KCNS3_HUMAN

	Western blot analysis of extracts of various cell lines, using KCNS3 antibody (CAB7906) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat ovary using KCNS3 antibody (CAB7906) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human colon carcinoma using KCNS3 antibody (CAB7906) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse spleen using KCNS3 antibody (CAB7906) at dilution of 1:100 (40x lens).

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)