The KCNQ4 Polyclonal Antibody (PAC049722) is a key tool for researchers studying the KCNQ4 protein, an essential component of potassium channels in the inner ear that play a crucial role in auditory function. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it a valuable asset for Western blotting applications.KCNQ4 is a voltage-gated potassium channel involved in the regulation of electrical signaling in auditory sensory cells.
Mutations in the KCNQ4 gene have been linked to hereditary hearing loss, making it a target of interest for investigating hearing-related disorders. By detecting and analyzing the expression of KCNQ4 protein in various cell types, researchers can gain insights into the mechanisms underlying auditory function and potential therapeutic targets for hearing loss conditions.
Antibody Name:
KCNQ4 Antibody (PACO49722)
Antibody SKU:
PACO49722
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Potassium voltage-gated channel subfamily KQT member 4 protein (401-516AA)
Immunofluorescent analysis of U251 cells using PACO49722 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
