The KCNQ4 Polyclonal Antibody (PAC022515) is a valuable tool for research involving KCNQ4, a potassium channel protein that plays a crucial role in auditory function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the KCNQ4 protein, researchers can accurately detect and analyze this important channel in various cell types, making it ideal for studies in auditory physiology and hearing loss research.KCNQ4 is essential for the function of hair cells in the inner ear, where it helps regulate the electrical signals necessary for hearing.
Mutations in the KCNQ4 gene are known to cause hereditary deafness, making it a key target for understanding the mechanisms of hearing and developing potential treatments for hearing loss disorders. By investigating the role of KCNQ4 in auditory function, researchers can gain valuable insights into the pathophysiology of hearing-related diseases and explore new therapeutic strategies for addressing them.
Antibody Name:
KCNQ4 Antibody (PACO22515)
Antibody SKU:
PACO22515
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from C-terminal of human KCNQ4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HuvEc cells, using KCNQ4 antibody.
Background:
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
