KCNQ2 Rabbit Polyclonal Antibody (CAB1917)
- SKU:
- CAB1917
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | KCNQ2 Rabbit Polyclonal Antibody |
SKU: | CAB1917 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-665 of human KCNQ2 (NP_742105.1). |
Sequence: | SPSA DQSL EDSP SKVP KSWS FGDR SRAR QAFR IKGA ASRQ NSEE ASLP GEDI VDDK SCPC EFVT EDLT PGLK VSIR AVCV MRFL VSKR KFKE SLRP YDVM DVIE QYSA GHLD MLSR IKSL QSRV DQIV GRGP AITD KDRT KGPA EAEL PEDP SMMG RLGK VEKQ VLSM EKKL DFLV NIYM QRMG IPPT ETEA YFGA KEPE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | EBN; BFNC; DEE7; EBN1; ENB1; HNSPC; KV7.2; KCNA11; KCNQ2 |
Positive Sample: | C6,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 96kDa |
Observed MW: | 95kDa |
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3785 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |