The KCNQ2 Polyclonal Antibody (CAB1917) is a valuable tool for researchers studying KCNQ2, a potassium channel protein associated with neurological disorders such as epilepsy. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.KCNQ2, also known as Kv7.2, is an important regulator of neuronal excitability and plays a key role in controlling the firing of neurons in the brain. Mutations in the KCNQ2 gene have been linked to various forms of epilepsy, making it a promising target for therapeutic interventions in the field of neurology.
By using the KCNQ2 Polyclonal Antibody, researchers can detect and analyze the expression of KCNQ2 in different cell types, providing valuable insights into the molecular mechanisms underlying neurological disorders. This antibody is a valuable tool for studies focusing on the pathophysiology of epilepsy, as well as for drug discovery efforts aimed at targeting KCNQ2 for the treatment of neurological conditions.
Product Name:
KCNQ2 Rabbit Polyclonal Antibody
SKU:
CAB1917
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 466-665 of human KCNQ2 (NP_742105.1).
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3785
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KCNQ2 Rabbit pAb (CAB1917) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
