The KCNN4 Polyclonal Antibody (CAB1974) is a valuable tool for researchers studying the KCNN4 protein, also known as the intermediate-conductance calcium-activated potassium channel 4. This antibody, generated in rabbits, specifically targets the KCNN4 protein and is highly reactive with human samples, making it ideal for use in Western blot applications.The KCNN4 protein plays a crucial role in the regulation of calcium-activated potassium channels, which are involved in various cellular processes, including membrane potential control and calcium signaling. Dysregulation of KCNN4 has been implicated in diseases such as cancer, neurological disorders, and cardiovascular conditions, making it a promising target for therapeutic interventions.
By using the KCNN4 Polyclonal Antibody, researchers can effectively detect and analyze the expression of KCNN4 in different cell types, providing valuable insights into its function and its potential role in disease development. This antibody is a valuable tool for studies in physiology, pharmacology, and molecular biology, offering new opportunities for investigating the mechanisms underlying KCNN4-related pathologies.
Product Name:
KCNN4 Rabbit Polyclonal Antibody
SKU:
CAB1974
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 288-427 of human KCNN4 (NP_002241.1).
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
Purification Method:
Affinity purification
Gene ID:
3783
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using KCNN4 antibody (CAB1974) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 1s.
