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KCNN3/SK3 Monoclonal Antibody (CAB23419)

SKU:
CAB23419
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

KCNN3/SK3 Monoclonal Antibody (CAB23419)

The KCNN3/SK3 Monoclonal Antibody (CAB23419) is a valuable tool for researchers studying the role of the KCNN3/SK3 protein in cellular signaling and ion channel regulation. This antibody specifically targets the KCNN3/SK3 protein, which is involved in the modulation of calcium-activated potassium channels.Raised in mice, this monoclonal antibody is highly specific and sensitive to human samples, making it ideal for use in various research applications such as immunofluorescence, immunoprecipitation, and flow cytometry. By targeting the KCNN3/SK3 protein, researchers can effectively study its function and its potential implications in diseases related to ion channel dysregulation.

The KCNN3/SK3 Monoclonal Antibody (CAB23419) opens up opportunities for further exploration into the mechanisms of ion channel regulation and the development of targeted therapies for conditions where KCNN3/SK3 dysregulation plays a role. Its high specificity and sensitivity make it a valuable tool for researchers in the fields of neuroscience, cardiology, and pharmacology.

Product Name:KCNN3/SK3 Monoclonal Antibody
Product Code:CAB23419
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC60792
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:PC-3, Mouse brain
Cellular Location:Membrane, Multi-pass membrane protein

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant protein of human KCNN3/SK3.
Sequence:Email for sequence
Synonyms:SK3, ZLS3, hSK3, SKCA3, KCa2.3
Calculated MW:81kDa
Observed MW:48kDa

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