KCNN3/SK3 Monoclonal Antibody (CAB23418)
- SKU:
- CAB23418
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | KCNN3/SK3 Monoclonal Antibody |
| Product Code: | CAB23418 |
| Reactivity: | Human |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC60790 |
| Reactivity: | Human |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Membrane, Multi-pass membrane protein |
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 630-730 of human KCNN3/SK3 (NP_002240.3). |
| Sequence: | DLSKM QNVMY DLITE LNDRS EDLEK QIGSL ESKLE HLTAS FNSLP LLIAD TLRQQ QQQLL SAIIE ARGVS VAVGT THTPI SDSPI GVSST SFPTP YTSSS S |
| Synonyms: | SK3, ZLS3, hSK3, SKCA3, KCa2.3 |
| Calculated MW: | 81kDa |
| Observed MW: | Refer to figures |
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