null

KCNN3/SK3 Monoclonal Antibody (CAB23418)

SKU:
CAB23418
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
IF
€139 - €529
Frequently bought together:

Description

KCNN3/SK3 Monoclonal Antibody (CAB23418)

The KCNN3 (SK3) Monoclonal Antibody (CAB23418) is a valuable tool for researchers studying the SK3 potassium channel, a critical player in the regulation of neuronal excitability and calcium signaling. This monoclonal antibody, produced using hybridoma technology, demonstrates high specificity and sensitivity towards human samples and is validated for use in various applications such as immunofluorescence and flow cytometry.The SK3 potassium channel, encoded by the KCNN3 gene, is known for its role in controlling the firing patterns of neurons and shaping synaptic transmission. Dysregulation of SK3 channels has been implicated in neurological disorders such as epilepsy and Parkinson's disease, making it a promising target for drug development and therapeutic interventions.

By utilizing the KCNN3 (SK3) Monoclonal Antibody (CAB23418), researchers can gain valuable insights into the expression and localization of SK3 channels in different cell types and tissues, leading to a better understanding of their physiological and pathological roles. This antibody is an essential tool for advancing research in neuroscience, pharmacology, and drug discovery aimed at targeting SK3 channels for the treatment of neurological disorders.

Product Name:KCNN3/SK3 Monoclonal Antibody
Product Code:CAB23418
Reactivity:Human
Applications:Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC60790
Reactivity:Human
Tested Applications:IF/ICC, ELISA
Key Applications:Immunofluorescence
Recommended Dilution:IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Cellular Location:Membrane, Multi-pass membrane protein

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 630-730 of human KCNN3/SK3 (NP_002240.3).
Sequence:DLSKM QNVMY DLITE LNDRS EDLEK QIGSL ESKLE HLTAS FNSLP LLIAD TLRQQ QQQLL SAIIE ARGVS VAVGT THTPI SDSPI GVSST SFPTP YTSSS S
Synonyms:SK3, ZLS3, hSK3, SKCA3, KCa2.3
Calculated MW:81kDa
Observed MW:Refer to figures

Related Products