The KCNN3 Polyclonal Antibody (CAB6125) is a valuable tool for researchers studying the KCNN3 gene, which encodes for a calcium-activated potassium channel involved in various physiological processes. This antibody, produced through rabbit immunization, is specifically reactive with human samples and has been validated for use in Western blot applications.By binding to the KCNN3 protein, this antibody allows for the detection and analysis of KCNN3 expression in different cell types, making it ideal for studies related to ion channel function, calcium signaling, and neuronal excitability.
The role of KCNN3 in regulating potassium ion flux and membrane potential highlights its importance in neurological disorders, such as epilepsy and neurodegenerative diseases.Understanding the molecular mechanisms underlying KCNN3 activity is essential for developing targeted therapies aimed at modulating potassium channel activity in the context of neurological disorders and other conditions. The KCNN3 Polyclonal Antibody (CAB6125) offers reliable data for in-depth investigations into the functional implications of KCNN3 in health and disease.
Product Name:
KCNN3 Rabbit Polyclonal Antibody
SKU:
CAB6125
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 237-426 of human KCNN3 (NP_740752.1).
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3782
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of NCI-H460 cells, using KCNN3 antibody (CAB6125) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
