KCNMB4 Antibody (PACO19891)
- SKU:
- PACO19891
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KCNMB4 Antibody (PACO19891)
The KCNMB4 Polyclonal Antibody (PAC019891) is a valuable tool for researchers studying the KCNMB4 protein, a key player in ion channel regulation and neuronal excitability. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the KCNMB4 protein, researchers can detect and analyze its expression in a variety of cell types, making it an essential tool for studies focused on neuroscience and ion channel function.KCNMB4, also known as the large-conductance calcium-activated potassium channel subfamily M regulatory beta subunit 4, plays a crucial role in modulating neuronal excitability by regulating potassium ion flow.
Its involvement in ion channel activity makes it a promising target for research into neurological disorders such as epilepsy, Alzheimer's disease, and Parkinson's disease. Understanding the function of KCNMB4 is essential for developing treatments that target ion channel dysfunction in these conditions, making this antibody a valuable asset for researchers in the field.
| Antibody Name: | KCNMB4 Antibody (PACO19891) |
| Antibody SKU: | PACO19891 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human KCNMB4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19891(KCNMB4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO19891(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19891(KCNMB4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming α subunit and the modulatory β subunit. The protein encoded by this gene is an auxiliary β subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the β 1 subunit. |
| Synonyms: | potassium large conductance calcium-activated channel, subfamily M, β member 4 |
| UniProt Protein Function: | JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 1q32.1Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity |
| UniProt Protein Details: | |
| NCBI Summary: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86W47 |
| NCBI GenInfo Identifier: | 26051275 |
| NCBI Gene ID: | 27345 |
| NCBI Accession: | NP_055320 |
| UniProt Secondary Accession: | Q86W47 |
| UniProt Related Accession: | Q86W47 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | calcium-activated potassium channel subunit beta-4 |
| NCBI Synonym Full Names: | potassium calcium-activated channel subfamily M regulatory beta subunit 4 |
| NCBI Official Symbol: | KCNMB4Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | calcium-activated potassium channel subunit beta-4 |
| UniProt Protein Name: | Lysine-specific demethylase 5B |
| UniProt Synonym Protein Names: | Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1 |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM5BÂ Â |
| UniProt Entry Name: |
| Antibodies |
| KCNMB4 Antibody (PACO01048) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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