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KCNMB4 Antibody (PACO01048)

SKU:
PACO01048
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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KCNMB4 Antibody (PACO01048)

The KCNMB4 Polyclonal Antibody (PACO01048) is a valuable tool for studying the KCNMB4 protein, which is involved in various cellular processes including ion channel regulation and smooth muscle contraction. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting KCNMB4 in human samples, making it suitable for Western blot applications.KCNMB4, a member of the large-conductance, calcium-activated potassium channel family, is known to modulate cellular excitability and play a role in cardiovascular function. Dysregulation of KCNMB4 has been implicated in cardiovascular diseases such as hypertension and arrhythmias, as well as in neurological disorders.

Therefore, studying the function and expression of KCNMB4 is essential for understanding its involvement in these pathologies and for developing potential therapeutic interventions. In conclusion, the KCNMB4 Polyclonal Antibody is an effective tool for researchers investigating the function and regulation of KCNMB4 in various physiological and pathological conditions, particularly in the fields of cardiovascular and neurological research.

Antibody Name:KCNMB4 Antibody
Antibody SKU:PACO01048
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human MaxiKBeta.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:KCNMB4; Calcium-activated potassium channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Hbeta4; Calcium-activated potassium channel; subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; K(VCA)beta-4; Maxi K channel sub
UniProt Protein Function:JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 1q32.1Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity
UniProt Protein Details:
NCBI Summary:MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
UniProt Code:Q86W47
NCBI GenInfo Identifier:26051275
NCBI Gene ID:27345
NCBI Accession:NP_055320
UniProt Secondary Accession:Q86W47
UniProt Related Accession:Q86W47
Molecular Weight:24kDa
NCBI Full Name:calcium-activated potassium channel subunit beta-4
NCBI Synonym Full Names:potassium calcium-activated channel subfamily M regulatory beta subunit 4
NCBI Official Symbol:KCNMB4  
NCBI Official Synonym Symbols:
NCBI Protein Information:calcium-activated potassium channel subunit beta-4
UniProt Protein Name:Lysine-specific demethylase 5B
UniProt Synonym Protein Names:Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1
Protein Family:Lysine-specific demethylase
UniProt Gene Name:KDM5B  
UniProt Entry Name:

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