The KCNMB2 Polyclonal Antibody (CAB10277) is a valuable tool for researchers studying KCNMB2, a protein involved in the regulation of calcium-activated potassium channels. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the KCNMB2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in pharmacology and neuroscience.
KCNMB2 plays a crucial role in modulating the activity of calcium-activated potassium channels, which are involved in regulating neuronal excitability and smooth muscle function. Understanding the function of KCNMB2 is essential for gaining insights into neurological disorders, cardiovascular diseases, and smooth muscle pathologies. By targeting KCNMB2 with this polyclonal antibody, researchers can explore its role in these conditions and potentially identify new therapeutic targets for treating related ailments.
Product Name:
KCNMB2 Rabbit Polyclonal Antibody
SKU:
CAB10277
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 68-194 of human KCNMB2 (NP_005823.1).
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described.
Purification Method:
Affinity purification
Gene ID:
10242
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KCNMB2 antibody (CAB10277) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
