The KCNMB1 Polyclonal Antibody (CAB10224) is specially developed for researchers studying KCNMB1, a potassium channel subunit involved in regulating smooth muscle contraction. This antibody is generated in rabbits and is highly specific for human samples, validated for use in various applications including Western blotting.KCNMB1 plays a key role in modulating vascular tone and blood pressure by regulating the activity of calcium-activated potassium channels. Dysregulation of KCNMB1 has been linked to cardiovascular diseases such as hypertension and atherosclerosis, making it a promising target for therapeutic interventions.
By using the KCNMB1 Polyclonal Antibody, researchers can accurately detect and analyze KCNMB1 protein levels in different cell types, aiding in the study of vascular physiology and the development of potential treatments for cardiovascular disorders. This antibody is an essential tool for investigations into the function and regulation of KCNMB1 in health and disease.
Product Name:
KCNMB1 Rabbit Polyclonal Antibody
SKU:
CAB10224
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human KCNMB1 (NP_004128.1).
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.
Purification Method:
Affinity purification
Gene ID:
3779
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KCNMB1 antibody (CAB10224) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
